“A building block of DNA or RNA- nucleotide is made up of the sugar, nitrogenous bases and phosphate while the nucleoside is made up of sugar and bases only.”
The nucleic acid is a genetic material involved in the inheritance of information and present in the nucleus of a cell.
The nucleic acid is made up of the three important ingredients- nitrogenous bases, sugar and phosphate.
These three’s are collectively called a nucleotide. A long chain of different nucleotides called a polynucleotide chain- forms a DNA molecule.
The sugar present on it either deoxyribose or ribose makes it DNA or RNA, respectively.
However, a nucleoside is insignificant for a cell and does not involve in construcing DNA.
The nucleosides are only made up of nitrogenous bases and sugar. The nucleoside is formed by the hydrolysis of nucleotides.
On the other side, during the process of phosphorylation, using the enzyme kinase, a phosphate group is attached to the sugar of the nucleic acid and constructs the nucleotide.
Thus through hydrolysis, the nucleotides converted into nucleosides while though the process of phosphorylation, the nucleosides are converted into nucleotides.
The nucleoside is a single molecule and does not have other variants whereas based on the number of phosphate group the nucleotides can be divided into nucleotide monophosphate, nucleotide diphosphate and nucleotide triphosphate with one, two and three phosphate backbones, respectively.
DNA is one of a well-known polymer of nucleotide triphosphates.
The artificial polynucleotide chains are used to cure different disorders using gene editing and gene transfer technology while some of the nucleoside analogues are used as anticancer and antiviral agents.
Examples of nucleotides- deoxyguanosine 5’- triphosphate, deoxyadenosine 5’ triphosphate, deoxyuridine 5’ triphosphate.
Examples of nucleosides- inosine, guanosine, uridine and adenosine.
Nucleotides are used to store and inherited information, signal transduction pathway and work as an energy source.
However, the nucleoside is important constructing nucleotides thus a nucleoside rich diet is required for staying healthy.
Actually, we can say, the nucleoside is an intermediated molecule helps in the proper construction of nucleotides.
Summary of the article:
|Made of sugar, nitrogenous bases and phosphate||Made of sugar and nitrogenous.|
|A polynucleotide chain is a building block of DNA or RNA.||Intermediate form in the construction of nucleotides.|
|Also works as an energy source and in signal transduction pathway.||Nucleoside rich diet is necessary for good health.|
|Examples of nucleotides- deoxyguanosine 5’- triphosphate, deoxyadenosine 5’ triphosphate, deoxyuridine 5’ triphosphate.||Examples of nucleosides- inosine, guanosine, uridine and adenosine.|
Conclusively, we can say DNA is made up of the polynucleotide chain whose building block is nucleotide, made up from the phosphorylation of nucleosides.